Endocrine Abstracts

The utility of renin measurement in guiding mineralocorticoid replacement is unclear. To address this we retrospectively examined the parameters and treatment of 97 patients with Addison’s disease over a five year period.Methods: Adrenal replacement, blood pressure (BP), orthostatic BP response, urea, sodium, potassium and renin levels of 97 patients attending our clinic were collected over the period 2012–2016. Data ...

The utility of renin measurement in guiding mineralocorticoid replacement is unclear. To address this we retrospectively examined the parameters and treatment of 97 patients with Addison’s disease over a five year period.Methods: Adrenal replacement, blood pressure (BP), orthostatic BP response, urea, sodium, potassium and renin levels of 97 patients attending our clinic were collected over the period 2012–2016. Data ...

Adrenal crisis (AC) is an acute life-threatening emergency contributing to excess mortality in patients with autoimmune adrenal insufficiency (AAI). Clinical, demographic and educational factors associated with high rates of AC admission remain unclear. We therefore examined the long-term clinical course of 91 patients with AAI.Methods: A retrospective observational study of 91 patients with AAI was performed. Electronic health records (...

Introduction: In rodents, dietary choline deficiency (CDD) results in macrovesicular hepatic steatosis and insulin sensitisation whereas methionine and choline deficient (MCDD) diets result in inflammatory fibrotic steatohepatitis with hepatic insulin resistance. The methyl donors choline and methionine are essential components of one-carbon metabolism. Our hypothesis was that methyl donor deficiency in mice would affect the expression of key genes in pathways of hepatic lipid...

Introduction: Non-alcoholic fatty liver disease (NAFLD) has become the most common form of chronic liver disease in children in association with the increasing prevalence of obesity. The underlying mechanisms are incompletely understood, however the accumulation of cholesterol and fatty acid lipotoxins plays an important role. 5-hydroxymethylcytosine (5hmC) is an epigenetic modification generated from 5-methylcytosine (5mC) by the Ten-eleven translocase isoenzymes (Tets). Tet ...